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- Both she and Reese Witherspoon previously collaborated in the 1996 exploitation movie Freeway before they voiced in Hanky Panky and High Anxiety.
- In 2005, Murphy won an Annie Award (Voice Acting in an Animated Television Production) for voicing Luanne in the episode "Girl, You'll Be a Giant Soon".
- On December 20, 2009, Murphy died of pneumonia and anaemia at the age of 32. Her death came roughly three months after the conclusion of ''King of the Hill''on FOX.
- Murphy was 19 years old when she started voicing Luanne Platter.